he debate on anesthetic effects in the developing brain has been stuck on mixed and often non-human data. FDA/NCTR used neural stem cell models and trusted VITROCELL SC3 Exposure Systems to keep xenon or desflurane, O₂, and CO₂ rock steady during long exposures. When the atmosphere stays steady, the biology speaks. Neuroprotection revealed: In human neurons, […]
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We put our VITROCELL Essentials Exposure Module to the test and ran a full internal uniformity study with diluted 1R6F reference cigarette smoke in both 12‑ and 24‑well formats – flows from 0.25 to 4 L/min. Spoiler: no drama, no divas, no “problem” positions. In our new Application Note AN‑15, we show that: Across all […]
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Our VITROCELL® 96 Exposure System has just been put through its paces in a new open‑access publication in Environmental Sciences Europe and it passed with flying colors. In this study, A549 cells at the air–liquid interface are exposed in a 96‑well format to: 11 aerosol concentrations + clean air controls – all in a single […]
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As part of the ADVISAR project, the effects of emissions from aircraft turbines are being comprehensively investigated from a chemical and physical perspective. In collaboration between Zurich University of Applied Sciences and Adolphe Merkle Institute, human lung cell cultures are now being exposed to diluted aircraft emissions from the engine test cell at SR Technics. […]
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First studies using our Cloud systems have already been successfully published (see link in the comments). Another widespread challenge is dry eye disease, where further studies are needed – and there’s a lot happening in the Eye-on-a-Chip community! For these applications, ultra-thin porous membranes, tunable mechanical properties, and compatibility with multiple readouts are key. For […]
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Vitrocell exposure systems enable direct air–liquid interface (ALI) exposure of mammalian cells and tissues to real-world airborne substances. From gases, complex mixtures, and combustion exhausts to cigarette smoke, e-cigarette vapor, household chemicals, nanomaterials, pharmaceutical aerosols, dry powders, and even viruses, Vitrocell supports high-quality in vitro inhalation research. Vitrocell helps teams generate reliable, reproducible data for […]
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In traditional submerged cell culture, airway cells are covered by liquid – a condition that does not reflect how humans actually breathe. At the Air–Liquid Interface (ALI), mammalian cells and tissues are exposed directly to airborne substances, replicating human respiratory physiology more closely and producing more predictive, human-relevant results. From toxicology to pharmaceutical development and […]
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Not all test atmospheres can be tested the same way. Some require the Continuous Flow Exposure Principle. In our Continuous Flow Exposure Systems, mammalian cells, tissues, and ex vivo material can be exposed to a constant flow of gases, complex mixtures, or particles – allowing both gas and particle phases to be assessed simultaneously. Furthermore, […]
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Following successful factory acceptance testing at Vitrocell in Waldkirch, we recently completed the final user training for the AirTox Monitor systems at LISA – Laboratoire Interuniversitaire des Systèmes Atmosphériques, (Université Paris Cité/Université Paris-Est Créteil (UPEC)/CNRS, France). What often matters most at this stage is not the system itself – but how confidently research teams can […]
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In a recently published study, researchers from the Institut de Recherche Biomédical des Armées (IRBA) and INERIS carried out repeated, sub-lethal co-exposures to aluminum oxide nanoparticles (Al₂O₃ NPs) and hydrogen chloride (HCl). A human air–liquid interface co-culture model of alveolar epithelial cells and fibroblasts was exposed using the VITROCELL Cloud System. Key findings: No loss […]
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